Th2-predominant inflammation and blockade of IFN-γ signaling induce aneurysms in allografted aortas
J. Clin. Invest. Koichi Shimizu, et al. 114:300 doi:10.1172/JCI19855 [Go to this article.]

Figure 7
Conventional RT-PCR (A) and real-time PCR (B) for MMP-12 from WT bone marrow×derived macrophages incubated 18 hours with IL-4 (10 ng/ml), IFN-γ (500 U/ml), and/or anti×IL-4 antibody (5 μg/ml, 11B11). IL-4 augmented and IFN-γ inhibited MMP-12 mRNA expression of the WT macrophages. In addition, 11B11 inhibited IL-4×induced augmentation of MMP-12 mRNA expression by the WT macrophages. Bar shows mean ± SEM (n = 6, each). *P < 0.0001.