Th2-predominant inflammation and blockade of IFN-γ signaling induce aneurysms in allografted aortas
J. Clin. Invest. Koichi Shimizu, et al. 114:300 doi:10.1172/JCI19855 [
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Figure 6Representative immunohistochemistry of CD4
+ (
A and
C) and CD11b
+ (
B and
D) cells in allografts from GRKO recipients harvested 4 weeks after transplantation (
n = 6). Boxed area in
A or
B (original magnification, ×100) is enlarged in
C or
D (original magnification, ×400), respectively. The majority of the graft infiltrating cells, especially adjacent to degraded elastic lamellae, consisted of CD11b
+ macrophages. Expression of MMP-12 (
F and
H) colocalized with CD11b
+ cells (
E and
G) in allografts from GRKO recipients harvested 4 weeks after transplantation (
n = 6).
