Th2-predominant inflammation and blockade of IFN-γ signaling induce aneurysms in allografted aortas
J. Clin. Invest. Koichi Shimizu, et al. 114:300 doi:10.1172/JCI19855 [Go to this article.]

Figure 3
Aortic allografts from GRKO recipients treated with anti–IL-4 antibody (A and C) or from DKO recipients (B and D) harvested at 12 weeks after transplantation. (A and B) Representative histologic appearance of transverse sections. (C and D) Elastic van Gieson staining. (E) Analysis of aortic diameter from the isograft (Iso) (n = 5), WT recipient allografts (n = 9), GRKO recipient allografts (n = 10), allografts in GRKO recipients with anti–IL-4 antibody (11B11) treatment (n = 3), and DKO (n = 6) recipient allografts 12 weeks after transplantation. *P < 0.01 vs. GRKO; **P < 0.0001 vs. GRKO.