Th2-predominant inflammation and blockade of IFN-γ signaling induce aneurysms in allografted aortas
J. Clin. Invest. Koichi Shimizu, et al. 114:300 doi:10.1172/JCI19855 [
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Figure 2Aortic allografts from WT (
A,
C,
E, and
G) or GRKO (
B,
D,
F, and
H) recipients 12 weeks after transplantation. (
A and
B) Representative gross appearance of aortas. (
C and
D) Echoaortograms. (
E and
F) Histologic appearance of transverse sections. (
G and
H) Elastic van Gieson staining (EVG). Analysis of 9–10 aortic transplants from different donors yielded similar results. Control (WT) experiments, shown in panels
A,
C,
E, and
G, did not reveal measurable aneurysm formation or elastic tissue degradation. Arrowheads indicate elastic lamellae.
