Renal Ca²⁺ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5
J. Clin. Invest. Joost G.J. Hoenderop, et al. 112:1906 doi:10.1172/JCI19826 [Go to this article.]

Figure 4
Bone phenotypes of female and male TRPV5^+/+ and TRPV5^–/– mice. (a) Representative cross-sectional x-ray images of the femoral head (I), the lesser trochanter (II), and the diaphysis (III) in TRPV5^+/+ and TRPV5^–/– mice. Note the decreased cortical bone width in the trochanter and diaphysis (arrows). (b) MOI as a parameter of bone quality. (c) Three-dimensional reconstruction of femurs from TRPV5^+/+ and TRPV5^–/– mice. Note the reduced cortical and Tb.Th in TRPV5^–/– mice. (d) Changes in serum levels of 1,25-(OH)₂D₃, PTH, and Ca²⁺ in TRPV5^+/+, TRPV5^+/–, and TRPV5^–/– mice. Values are expressed as percentage of TRPV5^+/+ values ± SEM. The absolute values for PTH are TRPV5^+/+, 55 ± 15 pg/ml; TRPV5^+/–, 59 ± 14 pg/ml; and TRPV5^–/–, 60 ± 16 pg/ml; for 1,25-(OH)₂D₃, TRPV5^+/+, 239 ± 38 pmol/l; TRPV5^+/–, 225 ± 32 pmol/l; TRPV5^–/–, 691 ± 88 pmol/l; and for free Ca²⁺ concentration, TRPV5^+/+, 1.20 ± 0.02 mM; TRPV5^+/–, 1.25 ± 0.03 mM; and TRPV5^–/–, 1.20 ± 0.03 mM. *P < 0.05, significant difference from wild-type mice.