Renal Ca²⁺ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5
J. Clin. Invest. Joost G.J. Hoenderop, et al. 112:1906 doi:10.1172/JCI19826 [Go to this article.]

Figure 2
Phenotypic characterization of TRPV5 knockout mice. (a) Body weights at an age of 8 weeks of TRPV5^+/+, TRPV5^+/–, and TRPV5^–/– mice (n = 29–43 mice). (b) The 24-hour urine volumes obtained from mice maintained in metabolic cages (n = 9 mice, three mice per cage). (c) Analysis of pH of urine obtained from TRPV5^+/+, TRPV5^+/–, and TRPV5^–/– mice (n = 9 mice, three mice per cage). (d) Total excretion of Ca²⁺, Na⁺, and K⁺ in TRPV5^+/+, TRPV5^+/–, and TRPV5^–/– mice (n = 9 mice, three mice per cage). Of note, TRPV5^+/– mice were similar to TRPV5^+/+ mice for the parameters measured. Data are averaged values ± SEM from mice at an age of 8 weeks. *P < 0.05, significant difference from TRPV5^+/+ mice.