Mast cells are required for experimental oral allergen–induced diarrhea
J. Clin. Invest. Eric B. Brandt, et al. 112:1666 doi:10.1172/JCI19785 [
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Figure 3Intestinal and systemic Th2 responses. (
a) Jejunum samples were collected 60 minutes after two, three, or four saline or OVA challenges and analyzed by RPA for Th1/Th2 cytokine expression. The positive control (+) (see Methods) expressed IL-4, IL-10, and IFN-γ. The housekeeping gene L32 was used as a control for RNA loading. Total IgE (
b), OVA-specific IgG1 (
c), and IgG2a (
d) plasma titers were measured following OVA or saline challenges (mean ± SEM;
n = 8–11 mice/group; *
P = 0.020;
#P = 0.003.)
