Mast cells are required for experimental oral allergen–induced diarrhea
J. Clin. Invest. Eric B. Brandt, et al. 112:1666 doi:10.1172/JCI19785 [Go to this article.]

Figure 2
Clinical features associated with allergic diarrhea. (a) Anaphylaxis was assessed by measuring hypothermia following either five intragastric saline or OVA challenges. As a control, systemic anaphylaxis was induced in OVA/alum–sensitized mice by an i.v. OVA (100 μg) injection. Body temperatures are expressed in degrees Celsius as mean ± SEM (n = 8 mice/group). (b) Systemic anaphylaxis was also induced in OVA/alum–sensitized and saline- (n = 7) or OVA- (n = 13) intragastric challenged mice by an intravenous injection of OVA (100 μg). Death occurred only in the intragastric OVA group (11 out of 13 mice). (c) Jejunum segments were isolated 1 hour after five to six saline or OVA challenges, and intestinal permeability to HRP was measured in an Ussing chamber over a 180-minute period (mean ± SEM; n = 8 mice/group; *P = 0.0012).