Sequence-specific modification of genomic DNA by small DNA fragments
J. Clin. Invest. Dieter C. Gruenert, et al. 112:637 doi:10.1172/JCI19773 [
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Figure 1Schematic representation of different SDF configurations possible in SFHR-mediated modification of a target sequence. The SDF can interact with the target sequence as (
a) sense and/or (
b) antisense ssDNA, or as (
c) dsDNA. The ssDNA can be introduced either as individual strands (sense and antisense) or as denatured cDNA strands. The enzymatic mechanisms involved require further elucidation.