Evidence for a bone-kidney axis regulating phosphate homeostasis
J. Clin. Invest. L. Darryl Quarles, et al. 112:642 doi:10.1172/JCI19687 [Go to this article.]

Figure 2
Osteoblasts express components necessary for coordinating mineralization of ECM and phosphate handling by the kidney. FGF-23 secreted from osteoblasts under the control of PHEX and possibly G_sα-dependent pathways has systemic actions to regulate renal phosphate handling as well as potential autocrine effects to regulate osteoblast-mediated bone mineralization. The LRP-Wnt signaling pathway in osteoblasts regulates bone mass and, in conjunction with PHEX and FGF-23, may also participate in coordinating renal phosphate conservation to meet the needs of osteoblast-mediated mineralization.