Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice
J. Clin. Invest. Yanhua Hu, et al. 113:1258 doi:10.1172/JCI19628 [Go to this article.]

Figure 7
Sca-1⁺/SM-LacZ cell transfer to vein grafts in mice. Sca-1⁺ cells were cultivated from the adventitia of SM-LacZ/ApoE^_/_ mice as described for Figure 5B. Irradiated vena cava of the mouse was removed and grafted into carotid arteries of ApoE^_/_ mice. Sca-1⁺/SM-LacZ cells (B_D) (10⁵) were applied onto the adventitia to envelop the vein grafts. Animals were sacrificed 2 weeks (B) or 4 weeks (A, C, and D) after surgery, and the grafted tissue fragments were sectioned and stained with X-gal. A shows a negative control without Sca-1⁺ cells. Arrows indicate β-gal⁺ cells.