Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation
J. Clin. Invest. Karen M. Dwyer, et al. 113:1440 doi:10.1172/JCI19560 [Go to this article.]

Figure 3
Expression of hCD39 protects transgenic mice from death due to induced thromboembolism. (A) Survival of WT mice (white bars) and transgenic mice (gray bars) after intravenous injection with ADP, collagen, or both agents. Between five and 14 mice were examined in each treatment group and the three mice in the controls that received saline. The survival advantage afforded by hCD39 was statistically significant for collagen alone and coadministration of ADP and collagen. (B) Histological examination of the lungs from mice treated with ADP and collagen demonstrating occlusion of small vessels (arrows) in the WT but not in the transgenic lung (magnification ∞40).