Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation
J. Clin. Invest. Joshua N. VanHouten, et al. 112:1429 doi:10.1172/JCI19504 [Go to this article.]

Figure 5
Bone density was measured in vivo at days 4 and 11 of lactation by DEXA. At day 4, the vertebral BMD of BLG-Cre/PTHrP^lox/– mice (n = 6) and controls (n = 5) was 0.05294 ± 0.002043 g/cm² and 0.05290 ± 0.002030 g/cm². By day 11 of lactation, the BMD of the control mice had fallen to 0.04368 ± 0.001386 g/cm², whereas the BMD of the BLG-Cre/PTHrP^lox/– mice was 0.04786 ± 0.001512 g/cm². Therefore, the BLG-Cre/PTHrP^lox/– mice lost significantly less bone mass during a 7-day time period during lactation than did controls (P < 0.01).