Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation
J. Clin. Invest. Joshua N. VanHouten, et al. 112:1429 doi:10.1172/JCI19504 [
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Figure 4Biochemical markers of bone turnover were lower in lactating
BLG-Cre/PTHrPlox/– mice. (
a) Urine CTx levels were significantly lower (
P < 0.05) in
BLG-Cre/PTHrPlox/– mice (3.98 ± 0.82 μg/mmol creatinine,
n = 8) than in controls (6.83 ± 0.29 μg/mmol creatinine,
n = 7). (
b) Osteocalcin concentrations in plasma were lower in
BLG-Cre/PTHrPlox/– mice than controls (48.4 ± 5.1 ng/ml,
n = 14, and 66.8 ± 12.5 ng/ml,
n = 9, respectively), but these values were not significantly different.
