Stat-3 is required for pulmonary homeostasis during hyperoxia
J. Clin. Invest. Isamu Hokuto, et al. 113:28 doi:10.1172/JCI19491 [
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Figure 9Decreased immunostaining for SP-B and proSP-C in
Stat-3Δ/Δ mice after exposure to 95% FiO
2. Staining for SP-B (
a–
d) and proSP-C (
e–
h) was performed in
Stat-3Δ/Δ and control littermates exposed to room air or 95% O
2. In room air there were no differences in intensity or distribution of SP-B and proSP-C staining between
Stat-3Δ/Δ and control mice. After 65 hours in 95% oxygen, SP-B and proSP-C staining were decreased in
Stat-3Δ/Δ (
d and
h) compared with controls (
b and
f). Scale bar: 100 μm. Photomicrographs are representative of
n ≥ 3.
