Stat-3 is required for pulmonary homeostasis during hyperoxia
J. Clin. Invest. Isamu Hokuto, et al. 113:28 doi:10.1172/JCI19491 [
Go to this article.]
Figure 7Abnormalities in pulmonary mechanics in
Stat-3Δ/Δ mice following hyperoxia. Lung mechanics were assessed in adult control and
Stat-3Δ/Δ mice exposed to room air or 95% O
2 for 65 hours. Lung mechanics were similar in control and
Stat-3Δ/Δ mice in room air. After exposure to 95% O
2, airway resistance, airway elastance, tissue damping, and tissue elastance were increased and compliance decreased significantly in
Stat-3Δ/Δ but not in control mice.
n = 5 per group. Statistical differences were analyzed by ANOVA. *
P < 0.01 versus control group.
