Stat-3 is required for pulmonary homeostasis during hyperoxia
J. Clin. Invest. Isamu Hokuto, et al. 113:28 doi:10.1172/JCI19491 [
Go to this article.]
Figure 6Increased alveolar capillary leak and decreased surfactant in
Stat-3Δ/Δ mice after hyperoxia. (
a) Total protein concentration was measured in lung lavage fluid 65 hours after exposure to 95% O
2. Protein content was similar in control and
Stat-3Δ/Δ mice in room air. After oxygen exposure, BALF protein recovered from each mouse (micrograms per kilogram) was significantly increased in the
Stat-3Δ/Δ mice,
n = 5 per group. *
P < 0.05 versus others and
P < 0.001 versus room air, as assessed by ANOVA. (
b) Surfactant saturated phosphatidylcholine (SatPC) was significantly decreased in BALF from the
Stat-3Δ/Δ mice following hyperoxia. Statistical differences were analyzed by ANOVA.
†P < 0.001 versus air.
