The endogenous cannabinoid system protects against colonic inflammation
J. Clin. Invest. Federico Massa, et al. 113:1202 doi:10.1172/JCI19465 [Go to this article.]

Figure 2
Histological micrographs showing H&E staining from transverse sections of the colon. (A and B) Colons from CB1^+/+ (A) and CB1^–/– (B) mice without DNBS treatment. (C and D) Colons from CB1^+/+ (C) and CB1^–/– (D) mice 3 days after DNBS treatment. (E and F) Colons from vehicle-treated (E) and SR141716A-treated (3 mg/kg) (F) C57BL/6N mice 3 days after DNBS treatment. In particular, note the severe mucosal infiltration with inflammatory cells, severe submucosal edema, and vascular alterations in CB1^–/– and SR141716A-treated mice. ML, muscular layer; M, mucosa; SM, submucosa. Scale bar: 100 μm.