Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell–mediated graft-versus-host disease model
J. Clin. Invest. Stephen C. Jones, et al. 112:1880 doi:10.1172/JCI19427 [
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Figure 3Minor histocompatibility antigen expression by the hematopoietic compartment results in cutaneous chronic GVHD. (
a–
d) Sclerotic dermis of skin from [BALB.B→B6] chimeric recipients, harvested day 90 after HCT, was distinguished by thickened dermis (vertical line,
a) containing randomly oriented and tightly compacted bundles of collagen (
c). In contrast, skin from [B6→B6] syngeneic controls had a normal dermal thickness (vertical line,
b) and contained mostly horizontally oriented, loosely packed bundles of collagen (
d). Original magnification:
a and
b, ×200;
c and
d, ×400. (
e) Mean dermal thickness ± SEM, in millimeters.
n = 5 for both groups.
