Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell–mediated graft-versus-host disease model
J. Clin. Invest. Stephen C. Jones, et al. 112:1880 doi:10.1172/JCI19427 [
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Figure 2Reduced epithelial injury over time in [BALB.B→B6] chimeric recipients. (
a–
c) Representative histopathological changes in ear biopsies taken on day 21 after HCT. Note the hyerplastic epithelial cell layer and epidermal cell apoptosis (arrows) in skin from [BALB.B→BALB.B] recipients (
a), compared with normal-looking skin from [BALB.B→B6] and [B6→B6] recipients (
b and
c, respectively). Original magnification: ×200. (
d) Sequentially analyzed dyskeratotic index following HCT. Apoptotic-cell counts were taken from more than 10 Lmm of epidermis per sample. Four animals were analyzed per group for all time points, except that only two animals from the [BALB.B→BALB.B] group were analyzed on days 21 and 32; SEM could not be calculated for these latter values (asterisk), but their mean was more than five times the SEM of the experimental and control groups.
