Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia
J. Clin. Invest. Fabio Ghiotto, et al. 113:1008 doi:10.1172/JCI19399 [
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Figure 2Different mechanisms generate an arginine at the V
L-J
L junctions. The codons for arginine are listed. Color code: identical nucleotides of the arginine codon are in brown, nucleotides deleted are in black, nucleotides probably resulting from nontemplated nucleotide addition are in dark blue, and differences within areas of identity or similarity in red. (A and B) An appropriate codon results from coding end trimming and recombination of the two germline
Vκ and
Jκ1 segments. (C) The arginine codon develops via a more complex combinatorial process, requiring the trimming of one nucleotide from the 3′ end of V
L, the deletion of seven nucleotides from the 5′ end of
Jκ2, and the nontemplated insertion of two G nucleotides.
