Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease
J. Clin. Invest. Hanspeter Waldner, et al. 113:990 doi:10.1172/JCI19388 [
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Figure 1Flow cytometry analysis of thymocytes and peripheral T cells in 5B6 transgenic B10.S mice. (A and B) T cells from thymi (A) and spleens (B) of mice were stained with the indicated antibodies (PE- or allophycocyanin-conjugated anti-CD4, FITC-conjugated anti-CD8, and PE-conjugated anti–TCR Vβ6). Dot plots representing two-color flow cytometry analysis of 5B6 transgenic mice with or without RAG-2 deficiency (TG/
RAG-2–/– or TG, respectively) and nontransgenic littermates (NLM) are shown. Numbers in quadrants refer to percentages of gated cell populations. Total numbers of spleen cells are shown above dot plots.
