Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization
J. Clin. Invest. Keiko Morikawa, et al. 112:1871 doi:10.1172/JCI19351 [
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Figure 4Endothelium-dependent and -independent hyperpolarizations of mesenteric arteries. (
a) Endothelium-dependent hyperpolarizations of mesenteric arteries in response to ACh (10
–5 M) were significantly attenuated in the
Cu,Zn-SOD–/– mice (
n = 4–5). **
P < 0.01 vs. WT. (
b) Endothelium-independent hyperpolarizations of mesenteric arteries in response to levcromakalim (10
–5 M) were comparable between the two strains (
n = 4–5).
