Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization
J. Clin. Invest. Keiko Morikawa, et al. 112:1871 doi:10.1172/JCI19351 [Go to this article.]

Figure 3
Preserved vascular smooth muscle cell responses in Cu,Zn-SOD^–/– mice. (a) Endothelium-independent relaxations in response to sodium nitroprusside (SNP) of mesenteric arteries from control mice and Cu,Zn-SOD^–/– mice (n = 6–8). (b) Endothelium-independent relaxations in response to NS-1619 of mesenteric arteries from control mice and Cu,Zn-SOD^–/– mice (n = 6–8). Those endothelium-independent relaxations were comparable between the two strains. (c) Exogenous H₂O₂-induced relaxations of mesenteric arteries without endothelium (n = 6 each). H₂O₂ caused a comparable extent of endothelium-independent relaxations in the two strains.