Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-γ
J. Clin. Invest. Beate Kampmann, et al. 115:2480 doi:10.1172/JCI19316 [Go to this article.]

Figure 5
Inhibition of HLA class II expression by IFN-γ–binding antibody. The antibody isolated from the serum of the patient is able to neutralize the function of IFN-γ: a 1:10 dilution of the antibody in the cell culture decreases the effect of IFN-γ in upregulating HLA-DR expression on monocytes. (A) Results expressed as mean fluorescence index (MFI) of HLA-DR on the surface of the monocyte population, based on triplicate measurements. (B) Representative plot defining HLA-DR positivity. A monocyte gate was applied to the PBMCs stained for HLA-DR.