Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions
J. Clin. Invest. Amrie C. Grammer, et al. 112:1506 doi:10.1172/JCI19301 [
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Figure 8Treatment of active-SLE patients with humanized anti-CD154 mAb (BG9588, 5c8) decreases anti-DNA Ab levels and the degree of proteinuria and improves SLEDAI. Changes in anti-dsDNA Ab levels, 24-hour urinary protein excretion (proteinuria), and SLEDAI are expressed on the left axis as percentage of base-line levels. Prednisone dose is shown on the right axis in mg/d. Vertical arrows indicate infusions of humanized anti-CD154 mAb (BG9588, 5c8). Horizontal arrows indicate additional immunosuppressive therapy. MMF, mycophenolate mofetil; CYC, cyclophosphamide.
