Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions
J. Clin. Invest. Amrie C. Grammer, et al. 112:1506 doi:10.1172/JCI19301 [
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Figure 6CD5 subsets of peripheral B cells diminish following treatment with humanized anti-CD154 Ab (h5c8). Freshly isolated PBMCs from active-SLE patients and normal volunteers were assessed for CD5 expression in B cell subsets by FACS analysis following staining with FITC-conjugated anti-IgD, PE-conjugated anti-CD19, and TC-conjugated anti-CD5. Histograms of CD5 expression on B cells from normal volunteers or active-SLE patients before treatment, during treatment (SLE nos. 1 and 2, 2 months; SLE no. 3, 1 month), or after withdrawal of treatment (SLE no. 1, 3 months after; SLE no. 2, 20 months after; SLE no. 3, 2 months after) are shown.
