Maturational differences in lung NF-κB activation and their role in tolerance to hyperoxia
J. Clin. Invest. Guang Yang, et al. 114:669 doi:10.1172/JCI19300 [
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Figure 8Inhibition of NF-κB activation in neonates injected with BAY. After 24 hours of hyperoxia, BAY-injected mice were injected with luciferin and anesthetized to allow for visualization (see Methods). (
A) Photon emission was quantified over the lung area (arrow) and expressed as a ratio to pre-O
2 for each animal. Pre-O
2 lane: images taken prior to injection and hyperoxia; O
2/PEG lane: mice injected with PEG (vehicle for BAY compounds); O
2/BAY lane: mice injected with BAY 11-7085. (
B) Values represent the mean ± SE of 3 experiments. *
P < 0.05 vs. polyethylglycol 400 (PEG) and uninjected. (
C) pI-κBα and Bcl-2 protein levels in C57BL/6 neonatal lung homogenates after 24 hours of hyperoxia and BAY injection.
