AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
J. Clin. Invest. Raymond R. Russell, et al. 114:495 doi:10.1172/JCI19297 [
Go to this article.]
Figure 4Glucose uptake, glycolysis, and GLUT expression in WT and KD hearts. Glucose uptake in hearts from KD transgenic (
n = 6) and WT (
n = 7) mice under baseline conditions, low-flow ischemia, and reperfusion (
A). Lactate release from the same hearts (
B). Stimulation of glucose uptake by insulin (1,000 μU/ml) in WT and KD hearts (
n = 3 for both) (
C) and immunoblot analysis of GLUT1 and GLUT4 expression in WT and KD hearts following baseline perfusion or ischemia/reperfusion (Isc/Rep) (
D). *
P < 0.05 versus baseline;
† P < 0.05 versus WT.
