Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance
J. Clin. Invest. Karsten Sydow, et al. 113:482 doi:10.1172/JCI19267 [Go to this article.]

Figure 6
Effects of GTN on cGMP responses of cultured PAECs with and without mitochondria (ρ⁰ cells). Increases in cGMP were markedly suppressed in cells without mitochondria. The insert at the top right-hand side shows a Western blot analysis for cytochrome c oxidase (in ρ⁰ cells, the expression is drastically reduced). Data are mean ± SEM from three to four separate experiments. *P < 0.05 vs. control; ^†P < 0.05 vs. cells with mitochondria.