Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance
J. Clin. Invest. Karsten Sydow, et al. 113:482 doi:10.1172/JCI19267 [Go to this article.]

Figure 2
Effects of ALDH-2 inhibition on cGK-I activity in rat aorta. Degree of VASP phosphorylation (P-VASP) and vasorelaxation by GTN and SNP in the presence and absence of the ALDH-2 inhibitor benomyl (beno) (1 μM). Benomyl attenuated GTN-induced (0.1 μM) but not SNP-induced (0.1 μM) activation of cGK-I. (a) Original Western blot; (b) densitometric quantification; (c) benomyl-induced inhibition of GTN-induced vasodilation (triangle). Data are mean ± SEM from three to five experiments. *P < 0.05 vs. control; ^#P < 0.05 vs. GTN.