Obesity is associated with macrophage accumulation in adipose tissue
J. Clin. Invest. Stuart P. Weisberg, et al. 112:1796 doi:10.1172/JCI19246 [
Go to this article.]
Figure 3The relationship between adipocyte size and the percentage of macrophages in adipose tissue. Average adipocyte cross-sectional area and the percentage of F4/80
+ cells (macrophages) in adipose tissue depots were determined for each mouse in this study. Average adipocyte cross-sectional area was a strong predictor of the percentage of F4/80
+ cells in (
a) perigonadal (
r2 = 0.76,
P < 10
–4), (
b) perirenal (
r2 = 0.73,
P < 10
–4), (
c) mesenteric (
r2 = 0.9,
P < 10
–4), and (
d) subcutaneous (
r2 = 0.39,
P < 0.01) adipose tissue depots. (
e) Data collected from all mice and all depots were plotted together. Light gray and dark gray symbols denote female and male mice, respectively.
+, lean; triangles,
Ay/+; squares, DIO; circles,
Lepob/ob mice.
