Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity
J. Clin. Invest. Lesley E. Smythies, et al. 115:66 doi:10.1172/JCI19229 [
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Figure 3Stimulus-independent down-regulation of intestinal macro-phage cytokine production. Blood monocytes and intestinal macrophages (2 × 10
6/ml) were incubated with and without
H. pylori urease (10 μg/ml), HK
S. aureus (10
7 CFU/ml), IFN-γ (100 U/ml), and PMA (40 ng/ml) for 24 hours, and supernatants were assayed for IL-1, IL-6, TNF-α, and IL-8. Values are mean + SD (
n = 3).