Cardiac hypertrophy and histone deacetylase–dependent transcriptional repression mediated by the atypical homeodomain protein Hop
J. Clin. Invest. Hyun Kook, et al. 112:863 doi:10.1172/JCI19137 [
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Figure 1Transgenic expression of Hop in the heart causes cardiac hypertrophy. (
a) Wild-type (left) and Hop transgenic (Tg) hearts at 8 weeks of age are shown. Scale bar: 1 mm. (
b) Heart weight–to–body weight ratios of Hop transgenic (black bars) and wild-type littermate (white bars) mice between 5 and 10 weeks of age are shown. Hop transgenic hearts are significantly enlarged. (
c) M-mode echocardiography demonstrates thickened myocardial walls in transgenic mice (red arrows) and hyperdynamic function with cavity obliteration. (
d) EKG-gated cardiac MRI reveals cardiac hypertrophy. Short-axis view images were captured during end diastole showing high contrast between blood (appearing bright) and myocardium. (
e) Mason’s trichrome staining of myocardium from wild-type 28-week-old mouse reveals normal cardiac histology. (
f) Identical staining technique and magnification of Hop transgenic littermate reveals massive myocyte hypertrophy and significant interstitial fibrosis (blue). (
e and
f) Scale bars: 50 μm.
