The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen
J. Clin. Invest. Seiji Kawamoto, et al. 114:399 doi:10.1172/JCI19082 [Go to this article.]

Figure 8
(A) Effect of pretreatment of BALB/C splenic DCs with C3a on their ability to support cytokine production by DO11.10 TCR-OVA transgenic T cells in response to OVA peptide. (B) Effect of supernatants of splenic DCs treated with C3a, then depleted of C3a, on cytokine production by DO11.10 TCR-OVA transgenic T cells in response to OVA peptide presented by fresh DCs. Columns and error bars represent mean ± SEM of three experiments. *P < 0.05. (C) Dose-response analysis of the effect of supernatants from C3a-stimulated DCs on IL-4 secretion. Sup, supernatant.