Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency
J. Clin. Invest. Gilles Faury, et al. 112:1419 doi:10.1172/JCI19028 [
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Figure 5Vascular IDs are similar at physiological blood pressures of
Eln+/– and
Eln+/+ genotypes. Comparison of ascending aorta IDs of
Eln+/+ and
Eln+/– mice at their respective physiological pressures shows that the vessel in
Eln+/– animals is smaller at every intravascular pressure. Because the basal blood pressure in the
Eln+/– genotype is higher, however, its effective working diameter (open arrows) is comparable to that of the wild-type animal (filled arrows). Solid lines show the working diameter of the wild-type artery at its physiological systolic (S) and diastolic (D) pressures (120/80). Dotted lines show that the systolic (s) and diastolic (d) dimensions of the
Eln+/– artery at its higher pressures (160/105) are similar to the wild-type values.
