Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model
J. Clin. Invest. Louise S. Villadsen, et al. 112:1571 doi:10.1172/JCI18986 [
Go to this article.]
Figure 4mAb 146B7 effectively alleviates psoriasis in a psoriasis SCID mouse xenograft model. SCID mice engrafted with human psoriatic skin were treated i.p. with PBS, mAb 146B7, or CsA. Skin grafts were harvested after treatment, embedded in paraffin, and stained with H&E (upper panels) or for Ki-67 nuclear antigen (lower panels). The tissue samples shown are from the same patient and are representative experiments with psoriatic skin obtained from four different patients.
