Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4⁺ T cells
J. Clin. Invest. Daphne C. Tsitoura, et al. 113:619 doi:10.1172/JCI18975 [Go to this article.]

Figure 8
Costimulation restores the Dex-mediated inhibition of c-Fos induction. Cell extracts were prepared from Dex-treated and control human naive CD4+ T cells stimulated with anti-CD3, anti-CD3 plus IL-2, or anti-CD3 plus anti-CD28. The induction of (a) c-Jun and (b) c-Fos expression was assessed by Western blotting using specific Ab’s. Results from a representative experiment are shown.