Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4⁺ T cells
J. Clin. Invest. Daphne C. Tsitoura, et al. 113:619 doi:10.1172/JCI18975 [Go to this article.]

Figure 7
Inhibition of MEK/ERK activity abrogates T cell resistance to Dex. Dex-treated and control murine naive CD4+ T cells were stimulated for 3 days with (a) anti-CD3 plus IL-2 or (b) anti-CD3 plus anti-CD28 in the presence of 10 μM (max) or 5 μM (half) of U0126. (c) Purified human naive CD4+ T cells were also stimulated with anti-CD3 plus anti-CD28 in the presence and absence of U0126. T cell proliferation was assessed by measuring 3H incorporation. Results are expressed as mean counts per minute (± SD) of triplicate cultures.