Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4⁺ T cells
J. Clin. Invest. Daphne C. Tsitoura, et al. 113:619 doi:10.1172/JCI18975 [Go to this article.]

Figure 1
Costimulation abrogates the inhibitory effect of Dex on TCR-induced proliferation. (a) Murine or (b) human Dex-treated and control naive CD4+ T cells were stimulated with anti-CD3, anti-CD3 plus IL-2, or anti-CD3 plus anti-CD28 for 3 days, and T cell proliferation was assessed by measuring 3H incorporation. Results are expressed as mean counts per minute (± SD) of triplicate cultures. *Reduction in proliferation is statistically significant.