Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis
J. Clin. Invest. Yaping Liu, et al. 112:1678 doi:10.1172/JCI18945 [
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Figure 4Protection against bile duct ligation–induced hepatotoxicity by GW4064. Rats (
n = 6) were subjected to bile duct ligation or laparotomy without bile duct ligation (sham-operated). Beginning 24 hours after bile duct ligation surgery, the rats were treated for 4 days with vehicle, GW4064, or TUDCA. Serum chemistries were measured 4 hours after the final dose. Values are presented as average ± SEM. White bars, sham; black bars, vehicle; dark gray bars, GW4064; light gray bars, TUDCA. Statistically significant differences between the sham-operated and vehicle/BDL groups are indicated (
#P < 0.05). Statistically significant differences between the vehicle/BDL group and either the GW4064-treated or the TUDCA-treated groups are also indicated (*
P < 0.05).
