Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis
J. Clin. Invest. Yaping Liu, et al. 112:1678 doi:10.1172/JCI18945 [Go to this article.]

Figure 1
Protection against ANIT-induced hepatotoxicity by GW4064. Rats (n = 6–8) were treated once daily with vehicle, GW4064, or TUDCA. On the second treatment day the rats received a single dose of ANIT or vehicle. Serum chemistries were measured 4 hours after the final dose. Values are presented as average ± SEM. White bars, vehicle/vehicle; black bars, vehicle/ANIT; dark gray bars, GW4064/ANIT; light gray bars, TUDCA/ANIT. Statistically significant differences between the vehicle/vehicle and vehicle/ANIT groups are indicated (^#P < 0.05). Statistically significant differences between the vehicle/ANIT group and either the GW4064/ANIT or the TUDCA/ANIT groups are also indicated (*P < 0.05).