A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans
J. Clin. Invest. Akihisa Sawada, et al. 112:1707 doi:10.1172/JCI18937 [
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Figure 4Enforced expression of mutant LRRC8. (
a) Constructs of the vectors. LTR, long terminal repeat; IRES, internal ribosomal entry site. (
b) Mutant LRRC8 was detected in the MutY-infected E86 cell line by Western blot. (
c) Representative data of murine peripheral blood cells obtained 3 months after transplantation. Thin lines represent YFP-negative control. Gr, granulocytes; Mo, monocytes. (
d) Statistical analysis of the ratio of YFP-positive cells in each lineage (MIY,
n = 4; MutY,
n = 3; Student’s
t test).
