Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle
J. Clin. Invest. Jason K. Kim, et al. 113:756 doi:10.1172/JCI18917 [
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Figure 4Insulin-signaling measurement in skeletal muscle (gastrocnemius) and hepatic insulin action of the WT (gray bars) and FATP1 KO (black bars) mice with lipid infusion or high-fat feeding. (A) Insulin-stimulated tyrosine phosphorylation of IRS-1 in skeletal muscle. (B) Insulin-stimulated IRS-1–associated PI3K activity in skeletal muscle. (C) Basal HGP. (D) HGP during hyperinsulinemic-euglycemic clamp procedures. Values are means ± SE for 5–6 experiments. *
P < 0.05 versus WT (control) mice.
