Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice
J. Clin. Invest. Ainhoa Iglesias, et al. 113:1398 doi:10.1172/JCI18879 [
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Figure 3Ultrastructural analysis of
E2F1/E2F2 double-homozygote pancreas sections. Exocrine (
A) and endocrine (
B) cells in pancreata from WT mice. Insets show the aspect of normal acinar and β cell granules. Pancreas from a 3-month-old male DKO mouse (
C_
F). Ductal structures composed of transitional cells with ductal cell features, but containing zymogen granules (
C), or both zymogen and endocrine granules, can be observed in DKO mice (
D). Cells containing both types of granules (pointed arrows, acinar granules; round arrows, endocrine granules) (
E and
F). Original magnification: (
A,
B,
E,
F) ∞3,400; (
C) ∞1,100; (
D) ∞2600; insets in
A and
B, ∞10,500.
