Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ
J. Clin. Invest. Andrew C. Li, et al. 114:1564 doi:10.1172/JCI18730 [
Go to this article.]
Figure 2Metabolic effects of PPAR ligands. Weight (
A), plasma insulin levels (
B), and size distribution (
C) of lipoprotein particles fractionated by FPLC. Measurements of weight and plasma insulin levels were taken at the indicated time points. FPLC analysis of lipoproteins was done using pooled plasma from terminal bleeds. Circles, control; diamonds, PPARα agonist GW7647; squares, PPARβ agonist GW0742. Data are expressed as mean ± SEM. *
P _ 0.05 compared with control. Measurements are from individual animals shown in Figure
1. Control,
n = 8; PPARα agonist,
n = 9; PPARβ agonist,
n = 10.
