Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ
J. Clin. Invest. Andrew C. Li, et al. 114:1564 doi:10.1172/JCI18730 [
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Figure 1Atherosclerosis in LDLR
–/– male mice that were fed the HC diet for 14 weeks. (
A) Sudan IV-_stained en face preparations of aortas. Scale bars: 1 cm. (
B) Quantitative analysis of atherosclerotic surface area in the entire aorta. (
C) Sections through the aortic root at the level of the aortic valves. The micrographs are taken of sections at a similar distance from the aortic root. Original magnification, ×4. (
D) Quantitative analysis of lesion areas in the aortic root. Data expressed as the mean ± SEM. C, control; α, PPARα agonist GW7647; β, PPARβ agonist GW0742; Abd, abdominal aorta; Arch, aortic arch. *
P < 0.001 and **
P _ 0.02, compared with control.
