Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats
J. Clin. Invest. Yoshitaka Iwanaga, et al. 113:727 doi:10.1172/JCI18716 [Go to this article.]

Figure 3
Serial changes of echocardiographic variables before and after S16EPLN gene transfer. (A) LVEDV. (B) LVESV. (C) LVEF. The S16EPLN treatment enhanced LV contractility and suppressed LV dilation over 6 months. Values are mean ± SE. *P < 0.05, MI-S16EPLN vs. MI-saline animals. ^#P < 0.05 vs. before gene transfer. Circles, no-MI; squares, MI-saline; triangles, MI-S16EPLN. (D–F) Representative images of pulse-wave Doppler recordings of mitral flow at 6 months in no-MI (D), MI-saline (E), and MI-S16EPLN rats (F).