Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance
J. Clin. Invest. Mathias Röhl, et al. 113:474 doi:10.1172/JCI18712 [Go to this article.]

Figure 2
GTG treatment results in obesity. (a) Growth curves of lean male mice (open squares) as compared with GTG-treated male mice (filled squares). Data represent the mean ± SEM of at least 16 animals in each group. Weights are significantly different between lean and obese mice from week 8 on (P < 0.05). (b) The body weight of GTG-treated male mice, according to their IKK2 genotype. Data represent the mean ± SEM of at least six animals in each group. (c) Plasma leptin concentrations in lean and obese mice, given as mean ± SEM of at least 16 animals in each group (*P < 0.01). (d) Plasma leptin concentrations in GTG-treated male mice of the indicated genotype, given as mean ± SEM of at least 6 animals in each group, revealed no significant differences depending on IKK2 expression.