A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT
J. Clin. Invest. Jennifer L. Gommerman, et al. 112:755 doi:10.1172/JCI18648 [
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Figure 6Infiltrates are detected in the CNS of day-59 EAE mice in control IgG but not LTβR-Ig–treated mice. Infiltrates and demyelination were compared between untreated naive SJL mice and control huIgG- or LTβR-Ig–treated SJL mice immunized with PLP
139–151 (day 59) as indicated. Fixed and paraffin-embedded spinal cords were sectioned both tangentially (
a,
b,
e,
f,
i,
j) and longitudinally (
c,
d,
g,
h,
k,
l), stained with either H&E (
a,
c,
e,
g,
i,
k) or with LFB for evaluation of myelin degradation (
b,
d,
f,
h,
j,
l), and visualized at ×50 with a Leica microscope. Representative sections from five animals are shown. Similar results were obtained at day 39 after immunization.
